If you use:  Reply-to= List,Respect

This allows that if the sender has specified his own email address in the "Reply-to" field in his message header, replies will go only to the sender's email address. Otherwise, the reply will go to the list. This option may cause some confusion for a person who expects his reply to go to the list in cases where the message he is replying to has a different "Reply-to" specified.

If you use:  Reply-to= List,Ignore

Any reply will go only to the list.

There are other options, and these are discussed on your listowner management webpages. In your webpage header, navigate  through:  List Management/List Configuration/List Configuration Wizard. Then click on the "Distribution" tab. Scroll down to "Reply-To", and click on the "?" next to it.

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