We're getting hammered by it too.  The spoofed addresses are more than likely being caused by the current outbreak of SoBig.F that's going around.  I had to hold a couple of lists for 3 days and move the held jobs out of the queue to keep LISTSERV running.
Noel Siksai
A+, RHCE
Avaya Corporate Email and Directory
Email backbone, Mass mail, Mailing lists, POST Tier 2 Admin.
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-----Original Message-----
From: Pete Weiss [mailto:[log in to unmask]]
Sent: Thursday, August 21, 2003 11:09 AM
To: [log in to unmask]
Subject: Re: Question -- faked "From:"s

At 10:29 08/21/2003 Thursday, Listserv Admin wrote:
 >Situation: We are getting loads of e-mail to various mailing lists, and
 >many have the same faked "From:" field.
 >
 >The "From:" field turns out to be real and actually belongs to a company
 >and is an auto-responder and as you can imagine, we've had a mailing loop
 >that crashed the machine before I was able to SERVE OFF the address.
 >
 >I've been talking to the owner of the company and he does NOT want to turn
 >off his auto-responder -- which is what I suggested he do temporarily.
 >What he does want, is to never get e-mail from us/Listserv again -- from
 >reading the documentation, I see no way to accomplish this, and as I type
 >this note to you all, Listserv continues to send his company e-mail for
 >each mail we receive for one of our mailing lists.  So, any
 >ideas/thoughts/options??

Maybe I'm missing something, BUT:

1) are the FROM: addresses subscribers of your list?

2) if they are legit subscribers, set them to REVIEW or perhaps NOPOST

3) if not subscribers, tighten your SEND= controls